Epilepsy Diagnosis and Treatments

Providing the most effective epilepsy treatment for your child largely depends on making sure we have a complete and accurate diagnosis. We understand that this process can be overwhelming, and our team at Norton Children’s Neuroscience Institute will guide your family every step of the way.

As an accredited Level 4 epilepsy center by the National Association of Epilepsy Centers, we offer advanced diagnostics and treatments, and provide the highest level of specialized, multidisciplinary care for difficult-to-treat epilepsy.

Treatment Options for Children With Epilepsy

Medication

About 70% of patients with epilepsy and seizures are treated successfully with antiseizure medications, giving these children long-term freedom from seizures. Our team of epilepsy specialists has vast experience with all medical options available, including cutting-edge medications.

After reviewing the child’s past and current list medications, as well as dosages, side effects and interactions with any other medications, we will make recommendations based on the type of seizure, the child’s age, side effects and cost. We will work with the family to choose the most appropriate medicine.

Our team will follow up frequently and monitor the treatment’s effectiveness. We will make adjustments as needed and review the medications on a regular basis.

For the 30% of patients who do not respond to medications, they are considered to have drug-resistant epilepsy, also called refractory epilepsy. Drug-resistant epilepsy is defined as failing to achieve seizure control after trying two medications.

Patients with drug-resistant epilepsy may benefit from other treatments, such as epilepsy surgery or the ketogenic diet. To determine which therapy is best for the patient, an in-depth evaluation, called a Phase 1 evaluation, is ordered.

Phase 1 Evaluations and Tests

Phase 1 evaluation consists of completing a set of tests to identify the type of seizures the patient has and determine which parts of the brain are causing the seizures. In addition to blood tests and taking a thorough medical history, Phase 1 will include a variety of diagnostic tests that includes some or all of the following:

  • Electroencephalography (EEG): This recording of brain waves with electrical receivers on the surface of the skin helps determine the seizure type.
  • Magnetic resonance imaging (MRI): This technology uses powerful magnets to scan and take a picture of the brain to identify brain structure abnormalities.

Functional Testing

  • Functional MRI (fMRI): The patient listens, thinks and moves as directed during an MRI to show which part of the brain correlates with each of those functions to help map the brain.
  • Positron emission tomography (PET): This type of scan uses computed tomography (CT) to evaluate areas of the brain that are metabolizing sugar faster or slower than other areas. This helps identify the area of the brain where partial seizures start.
  • Single photon emission computed tomography (SPECT): This test involves a CT scan that creates 3D images of blood flow to the brain during a seizure.
  • Neuropsychology evaluation: This is a detailed IQ test that evaluates different cognitive functions, such as memory, language and attention.

After the testing is completed, the child’s test results are reviewed during a weekly epilepsy surgery team conference attended by neurologists, neurosurgeons, radiologists, neuropsychologists and nurses all caring for patients with epilepsy. Each case is discussed carefully, and a collective plan is crafted to choose the best treatment option for each child.

Phase 2 Evaluations if Surgery Is Needed

If the patient’s seizures are focal, arising from one part of the brain, but Phase 1 testing cannot precisely map this area, a Phase 2 evaluation involves additional, more advanced testing to further map the brain and evaluate the possibility of surgery.

Phase 2 involves a surgery to carefully place very small EEG electrodes in selected parts of the brain that are chosen based on Phase 1 results. This procedure is called stereo EEG, or SEEG. Advanced software is used to take images of the brain and plan the location of the electrodes. This allows the team to accurately map where the seizures are happening in the brain and ensure that a corrective surgery can be done effectively and safely.

Surgery

From consultation through surgery and recovery, we guide families through each step of the surgery journey. Our multidisciplinary team includes pediatric neurosurgeons, epileptologists and neuropsychologists who will collaborate to create a personalized plan that is most suited for each child and family.

If the child meets the criteria for epilepsy surgery after the evaluation process, we will discuss the most appropriate treatment option, including minimally invasive procedures, to control or completely eliminate the child’s seizures.

As the region’s leader in pediatric epilepsy care, we offer sophisticated treatment options. Our dedicated surgical suite in Norton Children’s Hospital is specifically designed for complex pediatric procedures. The advanced tools allow our neurosurgeons to precisely map the child’s brain and plan the safest, most effective approach for their unique needs.

Who Is a Good Candidate for Epilepsy Surgery?

Any patient who has tried two or more medications and continues to have seizures can be considered for epilepsy surgery after completing Phase 1 testing.

The goal of surgery is to significantly reduce the severity and frequency of seizures, ideally eliminating them completely.

Your child’s provider will discuss the surgery type, if needed, and corresponding recovery therapy. The Norton Children’s Ketogenic Diet Clinic also may be recommended after treatment.

Your child’s epileptologist, a neurologist who is an epilepsy specialist, collaborates with a multidisciplinary team that includes a clinical pharmacist trained in caring for children with epilepsy.

Dietary Treatment

Research shows that some children who follow a ketogenic diet, modified Atkins diet or low glycemic diet experience a reduction in their seizures. These diets, which limit carbohydrate intake, are high in fat and moderate in protein. Scientists are still studying why this works. The thought is that this approach alters the brain’s excitability by fueling the body through fats and proteins.

Our multidisciplinary care team includes a dietitian, who can guide you and your child on meal plans that can help control epilepsy. This team of specialists with different training and experiences will bring a range of viewpoints and opinions as part of formulating your child’s customized care plan.

Children who are treated with epilepsy diets are monitored at the Norton Children’s Ketogenic Diet Clinic and have regular checkups to monitor growth, bone health, electrolytes and other health metrics.

Why Choose Norton Children’s Neuroscience Institute for Your Child’s Epilepsy Care?

  • Highest level of care: Since 2013, we’re home to Kentucky’s only Level 4 Comprehensive Epilepsy Center specifically for children, the highest rating available from the National Association of Epilepsy Centers.
  • Advanced surgical options: Epilepsy surgery is one of the most underused treatments available for refractory epilepsy, yet it is now safer and more effective than ever thanks to technological breakthroughs and depth of experience. All techniques are available at Norton Children’s.
  • Advanced surgical technology: Visualase, a real-time thermal imaging and laser system, allows our neurosurgeons to perform MRI-guided laser ablation surgery, a minimally invasive procedure; fewer than two dozen pediatric hospitals in the U.S. offer this technology.
  • Virtual reality planning: Surgical Theater creates an immersive 3D view of the brain, helping neurosurgeons, patients and families visualize specific brain regions contributing to and impacted by epilepsy and potential treatment impact; Norton Children’s Hospital is the first hospital in the region to use it.
  • Specialized neuropsychology support: Comprehensive assessments reveal how epilepsy impacts cognitive, emotional and behavioral development, providing detailed insights that inform treatment decisions, maximize results while minimizing treatment impact and support long-term success.
  • Dedicated inpatient epilepsy monitoring unit: Eight-bed unit at Norton Children’s Hospital, with an additional two beds at Norton Women’s & Children’s Hospital, allow children with epilepsy, unexplained seizures or other neurological episodes to receive continuous electroencephalography (EEG) monitoring and specialized care.
  • Comprehensive care team: Our dedicated team includes pediatric specialists, including epileptologists, neurologists, neurosurgeons, neuropsychologists, neuroradiologists, neurophysiologists, trained nurses, dietitians and social workers.
  • Convenient access statewide: Pediatric neurology clinics in Bowling Green, Elizabethtown, Frankfort, Owensboro, Paducah and Shepherdsville, Kentucky, plus telemedicine options provide closer follow-up, so families can receive specialized care closer to home.
  • Streamlined, family-centered care: In-office EEG and laboratory services are available at our downtown Louisville location.
  • Pioneering treatments: First in Kentucky and among few centers in the nation to use neurostimulation devices when seizures remain difficult to control. These include deep brain stimulation (DBS), responsive neurostimulation (RNS) and vagal nerve stimulation (VNS).