Active Clinical Trials at Norton Children’s

Learn more about participating in a clinical trial.

Active clinical trials at Norton Children’s and the UofL School of Medicine include:

Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Genetic Investigations in Atrial Arrhythmias
Study Type: Specimen Study
Chris L. Johnsrude, M.D.
Chris L. Johnsrude, M.D.
Principal Investigator
Norton Children's Heart Institute,
affiliated with the UofL School of Medicine
Sponsor: Lurie Children's Hospital

A Randomized Trial of a Mobile Health and Social Media Physical Activity Intervention among Adolescent and Young Adult Childhood Cancer Survivors
Study Type: Observational
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: COG

Acute Chest Syndrome

A Proposal to Enhance the Care of Acute Chest Syndrome Using Simulation Technology.
Study Type: Questionnaire
Aaron Calhoun, M.D.
Aaron Calhoun, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic L

A Randomized Web-based Physical Activity Intervention among Children and Adolescents with Acute Lymphoblastic Leukemia
Study Type: Registry
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic L

An Open-Label, Multicenter Study of RC-P in Patients with Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) Following Hypersensitivity to E. coli-derived Asparaginases
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Jazz Pharmaceuticals

Acute Myeloid Leukemia (AML)

A Phase 1/2 Study of CPX-351 (NSC# 775341; IND #129443) Alone Followed by Fludarabine, Cytarabine, and G-CSF (FLAG) for Children with Relapsed Acute Myeloid Leukemia (AML)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Alternative Medicine

Complementary and Alternative Medicine: Curriculum for Pediatric Residents
Study Type: Questionnaire
Bethany Hodge, M.D.
Bethany Hodge, M.D.
Principal Investigator
Norton Children's Hospital,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Anaphylaxis

Pediatric anaphylaxis management: variability across multiple institutions
Study Type: Questionnaire
Aaron Calhoun, M.D.
Aaron Calhoun, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Asthma

Intramuscular epinephrine as an adjunctive treatment for severe pediatric asthma exacerbation
Study Type: Observational
Kerry Caperell, M.D.
Kerry Caperell, M.D.
Principal Investigator
Norton Children's Emergency Medicine,
affiliated with the UofL School of Medicine
Sponsor: Thrasher Foundation

Asthma

Airway Microbiome and Age 6-Year Asthma in a Healthy Infant Cohort
Study Type: Observational
Michelle Stevenson, M.D.
Michelle Stevenson, M.D.
Principal Investigator
Norton Children's Emergency Medicine,
affiliated with the UofL School of Medicine
Sponsor: NIH

Asthma

Asthma Education in the Emergency Department
Study Type: Questionnaire
Kerry Caperell, M.D.
Kerry Caperell, M.D.
Principal Investigator
Norton Children's Emergency Medicine,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Asthma

IAA - Vitamin D Supplementation in Children with Obesity Related Asthma (VDORA1)
Study Type: Drug Study
Scott Bickel, M.D.
Scott Bickel, M.D.
Principal Investigator
Norton Children's Pulmonology,
affiliated with the UofL School of Medicine
Sponsor: IDeA States Pediatric Clinical Trials Network (ISP

Asthma

Evaluating the Respiratory Effect of Green Environmental Enhancement in Children with Asthma (The Green Lungs Study) GL1.3
Study Type: Observational
Scott Bickel, M.D.
Scott Bickel, M.D.
Principal Investigator
Norton Children's Pulmonology,
affiliated with the UofL School of Medicine
Sponsor: NIH

Autism

Treatment of children with autism spectrum disorders and epileptiform EEG with divalproex sodium. (VPA Autism Barnes 2013)
Study Type: Drug Study
Gregory Barnes, M.D.
Gregory Barnes, M.D.
Principal Investigator
Norton Children's Autism Center,
affiliated with the UofL School of Medicine
Sponsor: Children's Hospital Boston

B-Acute Lymphoblastic Leukemia (B-ALL)

A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518, IND#133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

B-Acute Lymphoblastic Leukemia (B-ALL)

A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

B-Acute Lymphoblastic Leukemia (B-ALL)

AALL1732: A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (IND#:133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Bacterial Infection

An Open label, Dose-finding, Pharmacokinetics, Safety, and Tolerability Study of Oritavancin Single Dose Infusion in Pediatric Subjects Less Than 18 Years of Age with Suspected or Confirmed Bacterial Infections
Study Type: Drug Study
Janice Sullivan, M.D.
Janice Sullivan, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: Melinta Therapeutics, Inc.

Bacterial Infection

A Phase 1, Open-Label, Two-Part Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of a Single Dose of Intravenous Lefamulin in Hospitalized Pediatric Subjects Receiving Standard of Care Antibiotic Therapy for Confirmed or Suspected Infection
Study Type: Drug Study
Janice Sullivan, M.D.
Janice Sullivan, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: Nabriva Therapeutics, DAC

Behavior

Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children with Cancer
Study Type: Observational
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Blood

A Process Improvement Project Using Educational and Skills Modules to Decrease Blood Culture Contamination Rates
Study Type: Questionnaire
Navjvot Vidwan, M.D., MPH
Navjvot Vidwan, M.D., MPH
Principal Investigator
Norton Children's Infectious Diseases,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Bronchiolitis

Airway Microbiome, Nasal microRNA, and Age 6-year Asthma Phenotypes in the MARC-35 Cohort
Study Type: Specimen Study
Michelle Stevenson, M.D.
Michelle Stevenson, M.D.
Principal Investigator
Norton Children's Emergency Medicine,
affiliated with the UofL School of Medicine
Sponsor: NIH

Bronchiolitis

EFFICACY OF MAGNESIUM SULFATE BOLUS IN PEDIATRIC PATIENTS WITH BRONCHIOLITIS
Study Type: Drug Study
John Berkenbosch, M.D.
John Berkenbosch, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: NH Investigator

Cancer

Renal tumors classifcation, biology and banking study.
Study Type: Specimen Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Cancer

COG ABTR04B1 ESTABLISHING CONTINUOUS CELL LINES AND XENOGRAFTS FROM PEDIATRIC CANCERS FOR BIOLOGICAL AND PRECLINICAL THERAPEUTIC STUDIES
Study Type: Specimen Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Cancer

Long-Term Follow-Up of Patients Previously Entered on Children's Cancer Group Clinical Trials (see below for list of studies)
Study Type: Observational
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Catecholaminergic Polymorphic Ventricular Tachycar

Improving Diagnosis and Treatment in CPVT
Study Type: Registry
Chris L. Johnsrude, M.D.
Chris L. Johnsrude, M.D.
Principal Investigator
Norton Children's Heart Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Hospital Boston

Catecholaminergic Polymorphic Ventricular Tachycar

ICD Therapy in Catecholaminergic Polymorphic Ventricular Tachycardia
Study Type: Questionnaire
Chris L. Johnsrude, M.D.
Chris L. Johnsrude, M.D.
Principal Investigator
Norton Children's Heart Institute,
affiliated with the UofL School of Medicine
Sponsor: Heart and Stroke Foundation of Canada

Catheter Ablation

Catheter Ablation with Reduction or Elimination of Fluoroscopy (CAREFL)—A Multi-center Registry
Study Type: Registry
Chris L. Johnsrude, M.D.
Chris L. Johnsrude, M.D.
Principal Investigator
Norton Children's Heart Institute,
affiliated with the UofL School of Medicine
Sponsor: Providence Medical Research Center

Central Nervous System Diseases

A Longitudinal Case-Control Study to Collect Clinical Data in Pediatric Immune-mediated Central Nervous System Diseases
Study Type: Observational
Michael Sweeney, M.D.
Michael Sweeney, M.D.
Principal Investigator
Norton Children's Neurology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Chronic Myeloid Leukemia (CML)

AAML1921-ITCC-054: A Phase I/II study of Bosutinib in pediatric patients with newly diagnosed chronic phase or resistant/intolerant Ph+ Chronic Myeloid Leukemia
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Classical Hodgkin Lymphoma (cHL)

An Open-label, Uncontrolled, Multicenter Phase II Trial of MK-3475 (Pembrolizumab) in Children and Young Adults with Newly Diagnosed Classical Hodgkin Lymphoma with Inadequate (Slow Early) Response to Frontline Chemotherapy (KEYNOTE 667).
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Merck Sharp & Dohme CORP

Congenital Heart Disease

Advanced Cardiac Therapies Improving Outcomes Network to Improve the Health of Pediatric and Congenital Heart Disease Patients with Heart Failure
Study Type: Registry
Sarah Wilkens, M.D.
Sarah Wilkens, M.D.
Principal Investigator
Norton Children's Heart Institute,
affiliated with the UofL School of Medicine
Sponsor: ACTION - Advanced Cardiac Therapies Improving Outc

COVID

A Phase 2/3 Single-Arm, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Remdesivir (GS-5734™) in Participants from Birth to < 18 Years of Age with COVID-19
Study Type: Drug Study
Kristina Bryant M.D.
Kristina Bryant M.D.
Principal Investigator
Norton Children's Infectious Diseases,
affiliated with the UofL School of Medicine
Sponsor: Gilead Sciences, Inc

COVID-19

A Phase 1, Open-Label, Dose-Finding Study to Evaluate Safety, Tolerability, and Immunogenicity and Phase 2/3 Placebo-Controlled, Observer-Blinded Safety, Tolerability, and Immunogenicity Study of A SARS-COV-2 RNA Vaccine Candidate Against Covid-19 in Healthy Children < 12 Years of Age
Study Type: Drug Study
Gary Marshall, M.D.
Gary Marshall, M.D.
Principal Investigator
Norton Children's Infectious Diseases,
affiliated with the UofL School of Medicine
Sponsor: Pfizer

CPS

Understanding African American parental concerns about child protective services involvement to improve access to pediatric medical and social care
Study Type: Questionnaire
Amber Pendleton M.D.
Amber Pendleton M.D.
Principal Investigator
Nortoon Children's Medical Group,
affiliated with the UofL School of Medicine
Sponsor: NH Foundation

Crisis Simulation

Medical and Relational Crisis Simulation (MARCS) for Pediatric Critical Care Fellows
Study Type: Questionnaire
Eleanor Peterson, M.D.
Eleanor Peterson, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Cystic Fibrosis

A Phase 3, Open-label Study Evaluating the Long-term Safety of VX-445 Combination Therapy in Subjects With Cystic Fibrosis
Study Type: Drug Study
Adrian O'Hagan M.D.
Adrian O'Hagan M.D.
Principal Investigator
Norton Children's Pulmonology,
affiliated with the UofL School of Medicine
Sponsor: Vertex Pharmaceuticals, Inc.

Cystic Fibrosis

A Master Protocol to Test the Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy (SIMPLIFY)
Study Type: Drug Study
Ronald L. Morton, M.D.
Ronald L. Morton, M.D.
Principal Investigator
Norton Children's Pulmonology,
affiliated with the UofL School of Medicine
Sponsor: Cystic Fibrosis Foundation, Inc. (CFF)

Data Collection

University of Louisville Kosair Charities Pediatric Clinical Research Unit Research Information for Subjects
Study Type: Registry
Janice Sullivan, M.D.
Janice Sullivan, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Dehydration

Implementation and Evaluation of Online Modules to Teach Pediatric Residents About IV Fluids and Dehydration
Study Type: Questionnaire
Sara Multerer, M.D.
Sara Multerer, M.D.
Principal Investigator
Norton Children's Hospital,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

The use of Rubrics of assessment of pediatric critical care trainees.
Study Type: Questionnaire
Katherine Potter, M.D.
Katherine Potter, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

Assessment of Pediatric Quality Improvement Curriculum
Study Type: Questionnaire
Sara Multerer, M.D.
Sara Multerer, M.D.
Principal Investigator
Norton Children's Hospital,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

Segmentation, Semantic Indexing, and Mining of Large Video Simulation Databases for Enhancing Medical Care During Crises
Study Type: Interventional
Aaron Calhoun, M.D.
Aaron Calhoun, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

Assessing Oral Health Curriculum in US Family Medicine and Pediatric Residency Programs: A National Survey
Study Type: Questionnaire
Ana Scholtz M.D.
Ana Scholtz M.D.
Principal Investigator
Nortoon Children's Medical Group,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

The Impact of an Academic Careers Symposium on Resident Career Choices
Study Type: Questionnaire
John Stutts, M.D.
John Stutts, M.D.
Principal Investigator
Norton Children's Gastroenterology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

Compassionate Options for Pediatric EMS (COPE)
Study Type: Questionnaire
Mary E. Fallat, M.D.
Mary E. Fallat, M.D.
Principal Investigator
Norton Children's Surgery,
affiliated with the UofL School of Medicine
Sponsor: HRSA-MATERNAL & CHILD HEALTH

Education

Effectiveness Of A Web-Based Educational Module For the Approach To Human Trafficking Victims In Clinical Practice
Study Type: Questionnaire
Carmen Tania Condurache, M.D.
Carmen Tania Condurache, M.D.
Principal Investigator
Norton Children's Hospital,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

A high tech nursing course for registered nurses in pediatric intensive care.
Study Type: Questionnaire
Katherine Potter, M.D.
Katherine Potter, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

Improving Safe Hand Offs in Kosair Children's Hospital NICU
Study Type: Questionnaire
Hannah R. Fischer, M.D.
Hannah R. Fischer, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

Formalization of Resident Participation in Code Events
Study Type: Questionnaire
Mary Sandquist M.D.
Mary Sandquist M.D.
Principal Investigator
Nortoon Children's Medical Group,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Education

Key adverse events following childhood cancer.
Study Type: Specimen Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Emergency Departments

Neonatal Abstinence Syndrome Discharge Plan of Safe Care: Accessing Pediatric Primary Care Provider Perceptions
Study Type: Questionnaire
Lori Devlin Phinney, D.O.
Lori Devlin Phinney, D.O.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Epilepsy and Autism

Safety and Tolerability of GWP42006 in Subjects with Drug Resistant Epilepsy and Autism—Extension Safety Study
Study Type: Drug Study
Gregory Barnes, M.D.
Gregory Barnes, M.D.
Principal Investigator
Norton Children's Autism Center,
affiliated with the UofL School of Medicine
Sponsor: GW Pharmaceuticals

Fetal Atrioventricular Block

Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly
Study Type: Drug Study
Jyothi Matta M.D.
Jyothi Matta M.D.
Principal Investigator
Norton Children's Heart & Vascular Institute,
affiliated with the UofL School of Medicine
Sponsor: NIH

Fontan

Detecting the Pathophysiology that Drives Fontan-associated Liver Disease
Study Type: Specimen Study
Joshua Kurtz M.D.
Joshua Kurtz M.D.
Principal Investigator
Norton Children's Heart & Vascular Institute,
affiliated with the UofL School of Medicine
Sponsor: American Academy of Pediatrics

Fontan Circulation

Clinical effects of respiratory motor training in patients with Fontan physiology.
Study Type: Observational
Sarah Wilkens, M.D.
Sarah Wilkens, M.D.
Principal Investigator
Norton Children's Heart Institute,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Genomics

Adolescent and Family Perspectives on Genome-Informed Pediatric Cancer Therapy
Study Type: Observational
Esther Elise Knapp, M.D.
Esther Elise Knapp, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Curing Kids Cancer

Genomics

NCI-COG PEDIATRIC MATCH (MOLECULAR ANALYSIS FOR THERAPY CHOICE) MASTER VERSION CONTROL PROTOCOL
Study Type: Registry
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Germ Cell Tumors

AGCT1531 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
Study Type: Observational
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Germ Cell Tumors

A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Hematopoietic Stem Cell Donors

Identifying Predictors of Poor Health-Related Quality-of-Life among Pediatric Hematopoietic Stem Cell Donors
Study Type: Observational
William Tse M.D.
William Tse M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Pediatric Blood and Marrow Transplant Consortium (

Hemopneumothorex

Presumptive Antibiotics in Tube Thoracostomy for Traumatic Hemopneumothorex: A prospective, Multicenter American Association for the Surgery of Trauma Study
Study Type: Observational
Mary E. Fallat, M.D.
Mary E. Fallat, M.D.
Principal Investigator
Norton Children's Surgery,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Hepatic Malignancy

Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Hepatitis C Virus (HCV)

A Long Term Follow-up Registry for Adolescent and Pediatric Subjects Who Received a Gilead Hepatitis C Virus Direct Acting Antiviral (DAA) in Gilead-Sponsored Chronic Hepatitis C Infection Trials
Study Type: Registry
Victoria A Statler, M.D.
Victoria A Statler, M.D.
Principal Investigator
Norton Children's Infectious Diseases,
affiliated with the UofL School of Medicine
Sponsor: Gilead Sciences, Inc

High-Grade Glioma

A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND #145355)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Hodgkin Lymphoma

A Phase III, Randomized Study of Nivolumab (Opdivo) or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: COG

ICU Patients

Establishment of a Podcast Curriculum for Residents Rotating Through a Pediatric Intensive Care Unit
Study Type: Questionnaire
Eleanor Peterson, M.D.
Eleanor Peterson, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Infant Health

Evaluation of Preterm Infants Fed Post-Discharge Preterm Infant Formula with Added Human Milk Oligosaccharide 2’-Fucosyllactose
Study Type: Drug Study
Scott Duncan, M.D.
Scott Duncan, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: Abbott Nutrition

Inflammatory Bowel Disease

Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents and Young Adults With Inflammatory Bowel Disease
Study Type: Registry
Maria Kahn, D.O.
Maria Kahn, D.O.
Principal Investigator
Norton Children's Gastroenterology,
affiliated with the UofL School of Medicine
Sponsor: Cincinnati Children’s Hospital Medical Center

Influenza

Epidemiology and Immune Response to Life-Threatening Influenza Infection in Children and Young Adults
Study Type: Specimen Study
Vicki Montgomery, M.D.
Vicki Montgomery, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: Pediatric Acute Lung Injury and Sepsis Investigato

Intermediate Risk (IR) Rhabdomyosarcoma (RMS)

COG ARST1431 A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating with Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864, IND# 122782) in Patients with Intermediate Risk (IR) Rhabdomyosarcoma (RMS)
Study Type: Drug Study
Kerry K. McGowan, M.D.
Kerry K. McGowan, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Intracranial Pressure

Infrared Pupillometry and the Neurological Pupil Index (NPi) in Children at Risk for Elevated Intracranial Pressure
Study Type: Observational
Janice Sullivan, M.D.
Janice Sullivan, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: NH Investigator

Intravascular

Bedside Ultrasound for Assessment of Intravascular Volume Status in Critically Ill Pediatric Patients
Study Type: Device Study
Michael Ruppe, M.D.
Michael Ruppe, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Intraventricular Hemorrhage

Investigating the Correlation between Doppler indices and Intraventricular hemorrhage in premature infants <29 weeks
Study Type: Observational
Hannah R. Fischer, M.D.
Hannah R. Fischer, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Invasive Aspergillosis or Invasive Mucormycosis

A Phase 2, Open-Label, Non-Comparative, Multicenter Study to Evaluate the Safety and Tolerability, Efficacy and Pharmacokinetics of Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Subjects
Study Type: Drug Study
Victoria A Statler, M.D.
Victoria A Statler, M.D.
Principal Investigator
Norton Children's Infectious Diseases,
affiliated with the UofL School of Medicine
Sponsor: Astellas Pharma Global Development Inc.

Jaundice

A phase 2B, mulit-center, single dose, blinded, randomized, placebo-controlled, dose escalation, safety and efficacy trial of Stannsoporfin in neonates with Hyperbilirubinemia.
Study Type: Drug Study
Dan Stewart, M.D.
Dan Stewart, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: InfaCare Pharmaceutical Corporation

Juvenile Arthritis

OBSERVATIONAL STUDY OF PEDIATRIC RHEUMATIC DISEASES:THE CARRA REGISTRY
Study Type: Registry
Kenneth Schikler, M.D.
Kenneth Schikler, M.D.
Principal Investigator
Norton Children's Rheumatology,
affiliated with the UofL School of Medicine
Sponsor: (CARRA) Childhood Arthritis and Rheumatology Resea

Juvenile Idiopathic Arthritis (JIA)

A Randomized, Open Label, Multi-Center, Phase 3 Efficacy Study of Sub-Q Abatacept (Orencia) in Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (LIMIT-JIA)
Study Type: Drug Study
Kenneth Schikler, M.D.
Kenneth Schikler, M.D.
Principal Investigator
Norton Children's Rheumatology,
affiliated with the UofL School of Medicine
Sponsor: PCORI

Langerhans Cell Histiocytosis

International Collaborative Treatment Protocol For Children And Adolescents With Langerhans Cell Histiocytosis
Study Type: Interventional
Kerry K. McGowan, M.D.
Kerry K. McGowan, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: North American Consortium for Histiocytosis

Laryngomalacia

Standardization of Diagnostic Criteria for Pediatric Laryngomalacia: a prospective study examining the efficacy of ultrasound use and correlation of cross-sectional supraglottal measurements with clinical symtoms scales
Study Type: Observational
Swapna Chandran, M.D.
Swapna Chandran, M.D.
Principal Investigator
Norton Children's ENT & Audiology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Left Ventricular Outflow Tract Obstruction

Optimal Management of Critical Left Ventricular Outflow Tract Obstruction: A Congenital Heart Surgeons' Society Study
Study Type: Observational
Bahaaldin Alsoufi M.D.
Bahaaldin Alsoufi M.D.
Principal Investigator
Norton Children's Heart & Vascular Institute,
affiliated with the UofL School of Medicine
Sponsor: NIH

Leukemia

A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2 Rearranged and/or JAK Pathway–Mutant Acute Lymphoblastic Leukemia
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Incyte Corporation

Low-Grade Glioma (LGG)

A Phase 3 Randomized Study of Selumetinib (IND # 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Low-Grade Glioma (LGG)

A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Medulloblastoma

NEWLY DIAGNOSED CHILDREN (LESS THAN 10 YEARS OLD) WITH MEDULLOBLASTOMA AND OTHER CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS: CLINICAL AND MOLECULAR RISK-TAILORED INTENSIVE AND COMPRESSED INDUCTION CHEMOTHERAPY FOLLOWED BY CONSOLIDATION WITH EITHER SINGLE CYCLE (LOW RISK PATIENTS) OR RANDOMIZATION (HIGH RISK PATIENTS) TO either SINGLE-CYCLE or TO THREE TANDEM CYCLES OF MARROW-ABLATIVE CHEMOTHERAPY WITH AUTOLOGOUS HEMATOPOIETIC PROGENITOR CELL RESCUE
Study Type: Drug Study
Michael Huang, M.D.
Michael Huang, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Nationwide Children's Hospital

Medulloblastoma

Phase II Trial of Eflornithine/DFMO as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma
Study Type: Drug Study
Michael Huang, M.D.
Michael Huang, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Beat Childhood Cancer

Medulloblastoma

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: COG

Migraine

A Randomized Trial Comparing Auricular Acupuncture and Intravenous Migraine Medications in the Treatment of Status Migrainosus in the Pediatric Emergency Department
Study Type: Observational
Danielle Graff M.D.
Danielle Graff M.D.
Principal Investigator
Norton ChIldren's Accupuncture,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Mortality

Longitudinal review of neonatal morbidity and mortality utilizing the Vermont Oxford Network Database.
Study Type: Observational
Scott Duncan, M.D.
Scott Duncan, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Neonatal Opioid Withdrawal Syndrome (NOWS)

Positive Parental Training to Improve Behavioral and Emotional Concerns in Children with a History of Neonatal Opioid Withdrawal Syndrome – Pilot Study
Study Type: Observational
Lori Devlin Phinney, D.O.
Lori Devlin Phinney, D.O.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Neuroblastoma

Utilizing Response and Biology Based Risk Factors to Guide Therapy in Patients with Non-High Risk Neuroblastoma
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Neuroblastoma

LEAHRN (Late Effects After High-Risk Neuroblastoma) Study
Study Type: Specimen Study
Kerry K. McGowan, M.D.
Kerry K. McGowan, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Neuroblastoma

PEDS-PLAN – Pediatric Precision Laboratory Advanced Neuroblastoma Therapy (A Study Using Molecular Guided Therapy with Induction Chemotherapy followed by a Randomized Controlled Trial of standard immunotherapy with or without DFMO followed by DFMO maintenance for Subjects with Newly Diagnosed High-Risk Neuroblastoma)
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Beat Childhood Cancer

Neuroblastoma

A Phase II Preventative Trial of DFMO as a Single Agent in Patients with High Risk Neuroblastoma in Remission (NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO))
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Beat Childhood Cancer

Neuroblastoma

A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab with or without Eflornithine (DFMO) (IND# 141913) in Children with Relapsed, Refractory or Progressive Neuroblastoma
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Neuroblastoma

A Pilot Study of Dinutuximab in Combination with Irinotecan and Temozolomide in the PostConsolidation Setting for High-Risk Neuroblastoma
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: COG

Neuroblastoma

Neuroblastoma Biology Study
Study Type: Specimen Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Neurological

Infrared Pupillometry and the Neurological Pupil Index in a Healthy Pediatric Population
Study Type: Observational
Janice Sullivan, M.D.
Janice Sullivan, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Neuromuscular Disorders

Muscular Dystrophy Association Neuromuscular Observational Research (MOVR) Data Hub Protocol
Study Type: Registry
Arpita Lakhotia, M.D.
Arpita Lakhotia, M.D.
Principal Investigator
Norton Children's Neurology,
affiliated with the UofL School of Medicine
Sponsor: Muscular Dystrophy Association

Obstructive Sleep Apnea (OSA)

Determination of a preliminary reference range for UCN3 in children.
Study Type: Specimen Study
Egambaram Senthilvel, M.D.
Egambaram Senthilvel, M.D.
Principal Investigator
Norton Children's Sleep Medicine,
affiliated with the UofL School of Medicine
Sponsor: National Institutes of Health

Patient care

Quantifying Diaper Need of Louisville, KY
Study Type: Questionnaire
Marian
Marian Morris, M.D.
Principal Investigator
Norton Children's Medical Group
Affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Pediatric Insulin

Coagulation and Fibrinolysis in a Pediatric Insulin Titration Trial
Study Type: Specimen Study
Kupper Wintergerst, M.D.
Kupper Wintergerst, M.D.
Principal Investigator
Norton Children's Endocrinology,
affiliated with the UofL School of Medicine
Sponsor: National Heart, Lung and Blood Institute (NHLBI)

Pediatric Peritoneal Dialysis

North American Pediatric Renal Transplant Cooperative Study (NAPTRCS)
Study Type: Registry
Siddharth Shah, M.D.
Siddharth Shah, M.D.
Principal Investigator
Norton Children's Nephrology,
affiliated with the UofL School of Medicine
Sponsor: North American Pediatric Renal Trials

Philadelphia Chromosome Ph+ALL

International Phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones.
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Post-intensive care syndrome

Post-Intensive Care Syndrome Pediatrics, Longitudinal Cohort study
Study Type: Observational
John Berkenbosch, M.D.
John Berkenbosch, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: NIH

Prostaglandin Level

Effect of peritoneal dialysis on serum prostaglandin levels in infants.
Study Type: Observational
Cynthia D. Downard, M.D.
Cynthia D. Downard, M.D.
Principal Investigator
Norton Children's Surgery,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Prostaglandin Level

Neonatal prostglandin serum levels before and after treatment for patient ductus arteriosus
Study Type: Observational
Cynthia D. Downard, M.D.
Cynthia D. Downard, M.D.
Principal Investigator
Norton Children's Surgery,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Respiratory Distress Syndrome (RDS)

A Partially-Blind, Randomized, Controlled, Parallel-Group Dose Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFactTM (SF-RI 1 surfactant for inhalation combined with a dedicated drug delivery system) in Preterm Infants at Risk of Worsening Respiratory Distress Syndrome
Study Type: Drug Study
Tonya Robinson, M.D.
Tonya Robinson, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: Aerogen Pharma Limited

Respiratory Pathogens

Influenza and Other Emerging Respiratory Pathogens Surveillance Registry
Study Type: Registry
Vicki Montgomery, M.D.
Vicki Montgomery, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: Abt Associates Inc

Respiratory Syncytial Virus (RSV)

A Phase 2/3 Randomized, Double-blind, Palivizumab-controlled Study to Evaluate the Safety of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in High-risk Children (MEDLEY)
Study Type: Drug Study
Tonya Robinson, M.D.
Tonya Robinson, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: MedImmune, LLC

RSV bronchiolitis

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, 2-PART STUDY TO EVALUATE EDP-938 REGIMENS IN SUBJECTS AGED 28 DAYS TO 36 MONTHS INFECTED WITH RESPIRATORY SYNCYTIAL VIRUS (RSV)
Study Type: Drug Study
Kristina Bryant M.D.
Kristina Bryant M.D.
Principal Investigator
Norton Children's Infectious Diseases,
affiliated with the UofL School of Medicine
Sponsor: Enanta Pharmaceuticals, Inc.

Screening

COG APEC14B1 - Project Every Child: A Registry, Eligibility Screening, Biology and Outcome Study
Study Type: Specimen Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Sepsis

The NICU Antibiotics and Outcomes Trial (NANO)
Study Type: Drug Study
Tamina R. Singh, M.D.
Tamina R. Singh, M.D.
Principal Investigator
Norton Children's Neonatology,
affiliated with the UofL School of Medicine
Sponsor: NIH

Septic Shock

Stress Hydrocortisone in Pediatric Septic Shock (SHIPSS)
Study Type: Drug Study
John Berkenbosch, M.D.
John Berkenbosch, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: NIH

Sickle Cell Disease (SCD)

A Comparative Effectiveness Study of Peer Mentoring [PM] versus Structured Transition Education Based Intervention [STE] for the Management of Care Transitions in Emerging Adults with Sickle Cell Disease (SCD)
Study Type: Observational
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: PCORI

Sickle Cell Disease (SCD)

A Non-Myeloablative Conditioning and Transplantation of Partially HLA-Mismatched and HLA-Matched Bone Marrow for Patients with Sickle Cell Disease and Other Hemoglobinopathies
Study Type: Specimen Study
William Tse M.D.
William Tse M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Vanderbilt-Ingram Cancer Center

Sleep Practices

Infant Safe Sleep Practices: Improving Pediatric Resident Knowledge and Ability to Discuss Infant Safe Sleep with Patient Families
Study Type: Questionnaire
Andrea Krause, M.D.
Andrea Krause, M.D.
Principal Investigator
Norton Children's Hospital,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Social/Behavioral/Educational

Descriptive Study of Parental Perceptions for 7 and 30-Day Readmissions
Study Type: Questionnaire
Klint Schwenk M.D.
Klint Schwenk M.D.
Principal Investigator
Nortoon Children's Medical Group,
affiliated with the UofL School of Medicine
Sponsor: UofL Investigator

Solid Tumors

A5481092 PHASE 1/2 STUDY TO EVALUATE PALBOCICLIB(IBRANCE®) IN COMBINATION WITH IRINOTECAN AND TEMOZOLOMIDE AND/OR IN COMBINATION WITH TOPOTECAN AND CYCLOPHOSPHAMIDE IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY SOLID TUMORS
Study Type: Drug Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Pfizer

Spinal Muscular Atrophy (SMA)

A Prospective Long-Term Registry of Patients with a Diagnosis of Spinal Muscular Atrophy (SMA)
Study Type: Registry
Arpita Lakhotia, M.D.
Arpita Lakhotia, M.D.
Principal Investigator
Norton Children's Neurology,
affiliated with the UofL School of Medicine
Sponsor: AveXis Inc

Spinal Muscular Atrophy (SMA)

Use of AVXS-101 for treatment of a patient with Spinal Muscular Atrophy (SMA) Type 1
Study Type: Drug Study
Arpita Lakhotia, M.D.
Arpita Lakhotia, M.D.
Principal Investigator
Norton Children's Neurology,
affiliated with the UofL School of Medicine
Sponsor: AveXis Inc

Supraventricular Tachycardia (SVT)

CARDIAC SOLAR Infant SVT Registry
Study Type: Registry
Chris L. Johnsrude, M.D.
Chris L. Johnsrude, M.D.
Principal Investigator
Norton Children's Heart Institute,
affiliated with the UofL School of Medicine
Sponsor: University of British Columbia

Transient Myeloproliferative Disorder (TMD)

Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS)
Study Type: Specimen Study
Ashok Raj, M.D.
Ashok Raj, M.D.
Principal Investigator
Norton Children's Cancer Institute,
affiliated with the UofL School of Medicine
Sponsor: Children's Oncology Group (COG)

Transport

Program for the Approach to Complex Encounter (PACE) – Pediatric Transport Team Outreach
Study Type: Questionnaire
Steven Peterson M.D.
Steven Peterson M.D.
Principal Investigator
Norton Heart & Vascular Institute
Sponsor: UofL Investigator

Trauma

Lessons learned following an episode of intensive care unit crisis: what experienced Intensivists can teach their peers
Study Type: Questionnaire
Aaron Calhoun, M.D.
Aaron Calhoun, M.D.
Principal Investigator
Norton Children's Critical Care,
affiliated with the UofL School of Medicine
Sponsor: Sir Charles Gairdner & Osborne Park Health Care Gr

Type 2 Diabetes (T2D)

Efficacy and safety of oral semaglutide versus placebo both in combination with metformin and/or basal insulin in children and adolescents with type 2 diabetes
Study Type: Drug Study
Kupper Wintergerst, M.D.
Kupper Wintergerst, M.D.
Principal Investigator
Norton Children's Endocrinology,
affiliated with the UofL School of Medicine
Sponsor: Novo Nordisk, Inc.

Undiagnosed Disorder

Sequence to Savings: A University of Louisville Health Economics Pilot Study
Study Type: Specimen Study
Alexander Asamoah, M.D., Ph.D.
Alexander Asamoah, M.D., Ph.D.
Principal Investigator
Norton Children's Genetics Center,
affiliated with the UofL School of Medicine
Sponsor: Commonwealth of Kentucky
Research

Support Research at Norton Children’s

Research at Norton Children’s is made possible thanks to the generosity of donors who wish to support important advances in pediatric health.
Donate today


Or call (502) 629-8060

Boy fighting cancer has passion for giving back

Methotrexate and vincristine are complex words for most, but 7-year-old Beckham Goodale knows them and can pronounce them just as well as any doctor. They’re words no child should know, but this is the reality [...]

Read Full Story

A 39-year career of discovery as kids with cancer and blood disorders were able to thrive

Thirty-nine years ago, Diane Burnett, APRN, wasn’t sure she was cut out to care for kids with cancer and blood disorders. Give it a year, she figured. “I didn’t know if I would be a […]

Read Full Story

Questions to ask about a child’s cancer diagnosis

When a child is diagnosed with cancer, it can be overwhelming for the patient and their entire family. Parents likely will have many questions, especially in the beginning, and providers encourage them to be inquisitive […]

Read Full Story

Exercise’s added benefits for childhood acute lymphoblastic leukemia survivors

The added benefits of exercise for survivors of acute lymphoblastic leukemia (ALL) can include psychological well-being, improved quality of life and lower risk of long-term effects — like broken bones or chronic diseases — from […]

Read Full Story

Childhood cancer survivor raises money for care and plans to become a nurse

Olivia “Liv” Miller was an active toddler and constantly on the go. When she started showing signs of fatigue and generally not being herself, her mother and father took her to their pediatrician in Owensboro, […]

Read Full Story
Related Stories

Boy fighting cancer has passion for giving back

Methotrexate and vincristine are complex words for most, but 7-year-old Beckham Goodale knows them and can pronounce them just as well as any doctor. They’re words no child should know, but this is the reality [...]

Read Full Story

A 39-year career of discovery as kids with cancer and blood disorders were able to thrive

Thirty-nine years ago, Diane Burnett, APRN, wasn’t sure she was cut out to care for kids with cancer and blood disorders. Give it a year, she figured. “I didn’t know if I would be a […]

Read Full Story

Questions to ask about a child’s cancer diagnosis

When a child is diagnosed with cancer, it can be overwhelming for the patient and their entire family. Parents likely will have many questions, especially in the beginning, and providers encourage them to be inquisitive […]

Read Full Story

Exercise’s added benefits for childhood acute lymphoblastic leukemia survivors

The added benefits of exercise for survivors of acute lymphoblastic leukemia (ALL) can include psychological well-being, improved quality of life and lower risk of long-term effects — like broken bones or chronic diseases — from […]

Read Full Story

Childhood cancer survivor raises money for care and plans to become a nurse

Olivia “Liv” Miller was an active toddler and constantly on the go. When she started showing signs of fatigue and generally not being herself, her mother and father took her to their pediatrician in Owensboro, […]

Read Full Story

Search our entire site.