Can a person get mono more than once? – Ethan* The Epstein-Barr virus (EBV) causes most cases of infectious mononucleosis. When someone gets mono, EBV stays in the body for the rest of that person's life. It can even reappear in the person's saliva (spit) from time to time. But the person probably won't get mono symptoms (like being tired all the time, a sore throat, fever, and loss of appetite) again — at least not from EBV. If you have mono symptoms — even if you've had it before — see your doctor. Other illnesses such as strep throat and the flu may cause similar symptoms. Your doctor can make an accurate diagnosis. *Names have been changed to protect user privacy. Back to Articles Related Articles How Long Is Mono Contagious? If someone gets mono, the virus stays in that person's body for life. The virus may surface from time to time and possibly infect someone else. Here are the facts on how mono works. Read More Mononucleosis (Mono) It's sometimes called "the kissing disease," but kissing is just one of the ways that someone can catch mono. Read More Can You Get Mono From Just a Quick Kiss? Find out what the experts have to say. Read More How Is Mono Spread? Find out what the experts have to say. Read More Can I Drink Alcohol If I Have Mono? Find out what the experts have to say. Read More Note: All information is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor. © 1995-2021 KidsHealth®. All rights reserved. Images provided by The Nemours Foundation, iStock, Getty Images, Veer, Shutterstock, and Clipart.com.