About Diphtheria

Diphtheria is a bacterial infection that spreads easily and occurs quickly. It mainly affects the nose and throat. Children under 5 and adults over 60 years old are particularly at risk for contracting the infection. People living in crowded or unclean conditions, those who aren't well nourished, and children and adults who don't have up-to-date immunizations are also at risk.

Diphtheria is very rare in the United States and Europe, where health officials have been immunizing children against it for decades. However, it's still common in developing countries where immunizations aren't given routinely. In 1993 and 1994, more than 50,000 cases were reported during a serious outbreak of diphtheria in countries of the former Soviet Union.

Signs and Symptoms

In its early stages, diphtheria can be mistaken for a bad sore throat. A low-grade fever and swollen neck glands are the other early symptoms.

The toxin, or poison, caused by the bacteria can lead to a thick coating (or membrane) in the nose, throat, or airway, which makes a diphtheria infection different from other more common infections that cause sore throat (such as strep throat). This coating is usually fuzzy gray or black and can cause breathing problems and difficulty in swallowing.

As the infection progresses, someone may:

  • have difficulty breathing or swallowing
  • complain of double vision
  • have slurred speech
  • even show signs of going into shock (skin that's pale and cold, rapid heartbeat, sweating, and an anxious appearance)

In cases that progress beyond a throat infection, diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs, such as the heart and kidneys. The toxin can cause damage to the heart that affects its ability to pump blood or the kidneys' ability to clear wastes. It also can cause nerve damage, eventually leading to paralysis. Up to 40% to 50% of those who don't get treated can die.

Prevention

Preventing diphtheria depends almost completely on giving the diphtheria/tetanus/pertussis vaccine to children (DTaP) and non-immunized adolescents and adults (Tdap). After a single dose of Tdap, adolescents and adults should receive a booster shot with the diphtheria/tetanus vaccine (Td) every 10 years. Most cases of diphtheria occur in people who haven't received the vaccine at all or haven't received the entire course.

The Tdap vaccine is also recommended for all pregnant women during the second half of each pregnancy, regardless of whether or not they had the vaccine before, or when it was last given.

The immunization schedule calls for:

  • DTaP vaccines at 2, 4, and 6 months of age
  • booster dose given at 12 to 18 months
  • booster dose given again at 4 to 6 years
  • Tdap vaccine given at 11-12 years
  • booster shots of Td given every 10 years after that to maintain protection
  • Tdap vaccine during the second half of each pregnant woman's pregnancy

Although most children tolerate it well, the vaccine sometimes causes mild side effects such as redness or tenderness at the injection site, a low-grade fever, or general fussiness or crankiness. Severe complications, such as an allergic reaction, are rare.

Contagiousness

Diphtheria is highly contagious. It's easily passed from an infected person to others through sneezing, coughing, or even laughing. It also can spread to someone who picks up tissues or drinking glasses that have been used by an infected person.

People infected with the diphtheria bacteria, even if they don't have any symptoms, can infect others for up to 4 weeks. The incubation period (the time it takes for a person to become infected after being exposed) for diphtheria is 2 to 4 days, although it can range from 1 to 6 days.

Treatment

Children and adults with diphtheria are treated in a hospital. After a doctor confirms the diagnosis through a throat culture, the infected person receives a special anti-toxin, given through injections or an IV, to neutralize the diphtheria toxin already circulating in the body, plus antibiotics to kill the remaining diphtheria bacteria.

If the infection is advanced, people with diphtheria may need a ventilator to help them breathe. In cases in which the toxins may have spread to the heart, kidneys, or central nervous system, patients may need intravenous fluids, oxygen, or heart medications.

A person with diphtheria must be isolated. Family members and other close contacts who haven't been immunized, or who are very young or elderly, must be protected from contact with the patient.

When someone is diagnosed with diphtheria, the doctor will notify the local health department and treat everyone in the household who may have been exposed to the bacteria. Treatment includes assessment of immune status, throat cultures, and booster doses of the diphtheria vaccine. They will also receive antibiotics as a precaution.

Immediate hospitalization and early intervention allow most patients to recover from diphtheria. After the antibiotics and anti-toxin have taken effect, someone with diphtheria will need bed rest for a while (4 to 6 weeks, or until full recovery). Bed rest is particularly important if someone develops myocarditis (inflammation of the heart muscle), which can be a complication of diphtheria.

Those who have recovered should still receive a full course of the diphtheria vaccine to prevent a recurrence because contracting the disease doesn't guarantee lifetime immunity.

When to Call the Doctor

Call your doctor immediately if anyone in your family has symptoms of diphtheria, if you observe symptoms in someone else, if anyone in your family is exposed to diphtheria, or if you think that you or a family member is at risk. It's important to remember, though, that most throat infections are not diphtheria, especially in countries that have routine immunizations against it.

If you're not sure if your kids have been vaccinated against diphtheria, make an appointment. Also make sure your own booster immunizations are current. International studies have shown that a significant percentage of adults over 40 years of age aren't adequately protected against diphtheria and tetanus.

Back to Articles

Related Articles

Word! Immunizations

This is the long word for what most kids know as shots.

Read More

Immunizations

Missing out on shots puts you at more serious risk than you might think. That one little "ouch" moment protects you from some major health problems.

Read More

Tetanus

Tetanus is a bacterial infection that grows in a contaminated wound. Because it can be serious, it's important to get immunized. Find out more.

Read More

Whooping Cough (Pertussis)

Pertussis is characterized by severe coughing spells that end in a whooping sound when the person breathes in. It can be prevented with the pertussis vaccine, part of the DTaP immunization.

Read More

Strep Test: Rapid

A rapid strep test is done to help quickly determine whether a sore throat is caused by a strep infection vs. other germs (usually viruses) that don't require antibiotic treatment.

Read More

Strep Throat

Strep throat is a common infection that usually needs to be treated with antibiotics. Find out how to recognize the signs of strep throat and what to expect if you have it.

Read More

Strep Test: Throat Culture

Is your child having a strep test or a throat culture? Find out how these swab tests are performed.

Read More

Strep Throat

Strep throat gives you a sore throat and makes it hard to swallow. Find out more in this article for kids.

Read More

Immunization Schedule

Which vaccines does your child need and when? Use this immunization schedule as a handy reference.

Read More

Common Questions About Immunizations

Immunizations have protected millions of children from potentially deadly diseases. Learn about immunizations and find out exactly what they do - and what they don't.

Read More

Your Child's Immunizations

Immunizations protect kids from many dangerous diseases. Find out what vaccines your child needs to grow up healthy.

Read More

Fevers

Fevers happen when the body's internal "thermostat" raises the body temperature above normal. This is often the body's way of fighting infections.

Read More

Note: All information is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor. © 1995-2021 KidsHealth®. All rights reserved. Images provided by The Nemours Foundation, iStock, Getty Images, Veer, Shutterstock, and Clipart.com.